Multidrug resistance (MDR) is already occurring among some equids in India.Donkeys and mules are a mobile species moving between regions and international borders, often populating areas of India where private community pharmacies, or medical stores, are the primary healthcare provider for both humans and animals.This article highlights how the cap
Antibody-drug conjugates (ADCs) are a class of biotherapeutic drugs designed as targeted therapies for the treatment of cancer.Among the challenges in generating an effective ADC is the choice of an effective conjugation site on the IgG.One common method to prepare site-specific ADCs is to engineer solvent-accessible cysteine residues into antibodi
Chromosomal translocations, which often generate chimeric proteins by fusing segments of two distinct genes, represent the single major genetic aberration leading to cancer.We suggest that the unifying theme of these events is a high level of intrinsic structural disorder, enabling fusion proteins to evade cellular surveillance mechanisms that elim
ABSTRACT Approximately 80% of the world population experiences some type of back pain at some point in their life, and in 10% of this population the pain causes chronic disability resulting in a high cost for the treatment of these patients, in addition to compromising their work and aptamil allerpro social interaction abilities.Current treatment s
A range of non-human animals frequently manipulate and explore objects in their environment, which may enable them to learn about physical properties and potentially form more abstract concepts of properties such as weight and rigidity.Whether animals can apply the information learned during their exploration to solve novel problems, however, and w